Bullous systemic lupus erythematosus: response to dapsone in two patients.

Bornhovd et al postulated persistence of parasites as cause of Th2 cells activation with increased IL5 and eosinophils secretion of proteolytic enzymes near BMZ (basement membrane zone) producing bullae formation. The exact mechanism for bullae formation is not known and further studies need to be done to explain the pathogenesis of bullous scabies. In a patient with itchy, vesiculobullous lesions, burrows should be looked for, as they are seen in majority of cases of bullous scabies.